Study Finds Source of Aging in Cells

A study conducted by the Salk Institute and the Chinese Academy of Science has published new data that is now considered to be a major advancement towards developing a better understanding of the aging process.

The scientists have found that the genetic mutations leading to Werner syndrome (a medical condition associated with premature aging) is caused by deterioration of DNA bundles known as heterochromatin.

The study has revealed that the same mechanism also happens with normal cells although at a much slower pace.

Juan Carlos Izpisua Belmonte, Ph.D., professor in the gene expression laboratory at the Salk Institute and senior author on the paper said, "Our findings show that the gene mutation that causes Werner syndrome results in the disorganization of heterochromatin, and that this disruption of normal DNA packaging is a key driver of aging."

"This has implications beyond Werner syndrome, as it identifies a central mechanism of aging-heterochromatin disorganization-which has been shown to be reversible."

Scientists are hopeful that a greater understanding of this process will be helpful to treat age related medical conditions like diabetes, Alzheimer's and even cancer.

"Our study connects the dots between Werner syndrome and heterochromatin disorganization, outlining a molecular mechanism by which a genetic mutation leads to a general disruption of cellular processes by disrupting epigenetic regulation," stated Dr. Izpisua Belmonte. "More broadly, it suggests that accumulated alterations in the structure of heterochromatin may be a major underlying cause of cellular aging. This begs the question of whether we can reverse these alterations-like remodeling an old house or car-to prevent, or even reverse, age-related declines and diseases."