Chinese Scientists Test Genetic Modification Of Human Embryos With CRISPR

The CRISPR/Cas9 gene editing technique created an outcry due to its potential to alter the human genome. Chinese scientists from Guangzhou Medical University have now genetically modified a human embryo with the technique. However, they explain that they performed it on embryos with extra chromosomes, which were unviable.

While most scientists have hesitated to get involved in altering the human genome, China's experiments have been ongoing. Just a year ago, a team of Chinese researchers undertook an experiment  involving genetic modification of human embryo genes.

With 213 fertilized eggs from a fertility clinic classified as "unsuitable" for in vitro therapy due to the extra set of chromosomes, the scientists used every egg donated, agreeing to the condition that they would not be permitted to develop into human beings.

With the CRISPR technique, the team added another mutation  that destroyed the immune cell gene CCR5. This cell type was said to promote HIV resistance when it got damaged so that it could better comprehend the potential of genetic modification to enable babies to develop HIV resistance.

By genetically modifying four out of 26 embryos, scientists found that some of the embryos developed unforeseen mutations while others contained untouched genes.

While scientists have not ventured too deeply into the unchartered area, Chinese researchers are not willing to hesitate to conduct their experiments.

While gearing up for the public backlash that will visit them, team members say that the research is indicating further CRISPR/Cas9 gene editing efforts.They explain that the intention is not to permit human embryos to mature, but it is motivated by a desire to locate advantages through gene modification.

The findings were published in the April 6 issue of the Journal of Assisted Reproduction and Genetics.